Proto-Oncogene Tyrosine-Protein Kinase ROS

Preferred Label : Proto-Oncogene Tyrosine-Protein Kinase ROS;

NCIt synonyms : ROS1 Protein; ROS1; gp280; c-Ros Receptor Tyrosine Kinase; c-Ros Tyrosine Kinase; Receptor Tyrosine Kinase c-Ros Oncogene 1; Proto-Oncogene c-Ros; EC 2.7.10.1; Proto-Oncogene c-Ros-1;

NCIt definition : Proto-oncogene tyrosine-protein kinase ROS (2347 aa, 264 kDa) is encoded by the human ROS1 gene. This protein is involved in cell growth, tyrosine phosphorylation and receptor-mediated signaling.;

Details

Origin ID

C17691;

UMLS CUI

C1310668;

OMIM relation
- Ros protooncogene 1, receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ROS1 protein, human [MeSH concept]
- ROS1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- ROS1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- ALK/ROS1 Inhibitor TGRX-326 [NCIt concept]
- ALK/ROS1 Inhibitor XZP-3621 [NCIt concept]
- Lorlatinib [NCIt concept]
- ROS1/TRK/ALK Inhibitor TY-2136b [NCIt concept]
- Repotrectinib [NCIt concept]
- TRK/ROS1/ALK Inhibitor SIM1803-1A [NCIt concept]
- Zidesamtinib [NCIt concept]
- pan-TRK/ROS1 Dual Inhibitor XZP-5955 [NCIt concept]

Keyword's position in hierarchy(ies) :

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