Preferred Label : Deulorlatinib;
NCIt synonyms : ALK/ROS1 Inhibitor TGRX-326;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinases anaplastic lymphoma
kinase (ALK) and c-ros oncogene 1 (ROS1), with potential antineoplastic activity.
Upon oral administration, deulorlatinib targets, binds to and inhibits the activity
of ALK and ROS1, which leads to the disruption of ALK- and ROS1-mediated signaling
and the inhibition of cell growth in ALK- and ROS1-expressing tumor cells. ALK belongs
to the insulin receptor superfamily and plays an important role in nervous system
development. ALK is not expressed in healthy adult human tissue but ALK dysregulation
and gene rearrangements are associated with a variety of tumor cell types. ROS1, overexpressed
in certain cancer cells, plays a key role in cell growth and survival of cancer cells.;
UNII : 7PW3UT8C9B;
CAS number : 2131126-33-3;
Molecule name : TGRX 326; TGRX-326;
NCI Metathesaurus CUI : CL1794263;
Origin ID : C189066;
UMLS CUI : C5706533;
Semantic type(s)
- concept_is_in_subset
- has_target
