ALK Tyrosine Kinase Receptor

Preferred Label : ALK Tyrosine Kinase Receptor;

NCIt synonyms : ALK; CD246 Antigen; Anaplastic Lymphoma Kinase; EC 2.7.10.1;

NCIt definition : ALK tyrosine kinase receptor (1620 aa, 176 kDa) is encoded by the human ALK gene. This protein is involved in ligand binding, tyrosine phosphorylation and signal transduction.;

NCIt note : ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. (LocusLink);

Details

Origin ID

C27032;

UMLS CUI

C1663627;

Currated CISMeF NLP mapping
- Anaplastic Lymphoma Kinase [MeSH Descriptor]
False automatic mappings
- anaplastic lymphoma kinase [MeSH concept]
OMIM relation
- Anaplastic lymphoma kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ALK protein, human [MeSH concept]
- ALK protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ALK Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Crizotinib [NCIt concept]
gene_product_has_abnormality
- ALK Kinase Overexpression [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- ALK NP_004295.2:p.F1174C [NCIt concept]
- ALK NP_004295.2:p.F1174L [NCIt concept]
- ALK NP_004295.2:p.F1174V [NCIt concept]
- ALK NP_004295.2:p.F1174X [NCIt concept]
- ALK NP_004295.2:p.F1245I [NCIt concept]
- ALK NP_004295.2:p.F1245L [NCIt concept]
- ALK NP_004295.2:p.F1245X [NCIt concept]
- ALK NP_004295.2:p.G1128A [NCIt concept]
- ALK NP_004295.2:p.G159 Frameshift [NCIt concept]
- ALK NP_004295.2:p.I1170N [NCIt concept]
- ALK NP_004295.2:p.I1170S [NCIt concept]
- ALK NP_004295.2:p.I1171N [NCIt concept]
- ALK NP_004295.2:p.K1062M [NCIt concept]
- ALK NP_004295.2:p.L1196M [NCIt concept]
- ALK NP_004295.2:p.M1166R [NCIt concept]
- ALK NP_004295.2:p.R1192P [NCIt concept]
- ALK NP_004295.2:p.R1275L [NCIt concept]
- ALK NP_004295.2:p.R1275Q [NCIt concept]
- ALK NP_004295.2:p.R1275X [NCIt concept]
- ALK NP_004295.2:p.T1087I [NCIt concept]
- ALK NP_004295.2:p.Y1278S [NCIt concept]
- ALK Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- ALK Inhibitor ASP3026 [NCIt concept]
- ALK Inhibitor NVL-655 [NCIt concept]
- ALK Inhibitor PLB 1003 [NCIt concept]
- ALK Inhibitor SY-3505 [NCIt concept]
- ALK Inhibitor TAE684 [NCIt concept]
- ALK-FAK Inhibitor CEP-37440 [NCIt concept]
- ALK/FAK/Pyk2 Inhibitor CT-707 [NCIt concept]
- ALK/ROS1 Inhibitor TGRX-326 [NCIt concept]
- ALK/ROS1 Inhibitor XZP-3621 [NCIt concept]
- ALK/TRK Inhibitor TSR-011 [NCIt concept]
- Alectinib [NCIt concept]
- Belizatinib [NCIt concept]
- Brigatinib [NCIt concept]
- Carbon C 14 Gilteritinib [NCIt concept]
- Ceritinib [NCIt concept]
- Crizotinib [NCIt concept]
- Ensartinib [NCIt concept]
- Ensartinib Hydrochloride [NCIt concept]
- Entrectinib [NCIt concept]
- Envonalkib [NCIt concept]
- Ficonalkib [NCIt concept]
- Gilteritinib [NCIt concept]
- Gilteritinib Fumarate [NCIt concept]
- Iruplinalkib [NCIt concept]
- Lorlatinib [NCIt concept]
- ROS1/TRK/ALK Inhibitor TY-2136b [NCIt concept]
- Repotrectinib [NCIt concept]
- TRK/ROS1/ALK Inhibitor SIM1803-1A [NCIt concept]
- Zotizalkib [NCIt concept]

Keyword's position in hierarchy(ies) :

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