Autologous Anti-ALK CAR T-cells

Preferred Label : Autologous Anti-ALK CAR T-cells;

NCIt synonyms : Autologous Anti-ALK CAR T Cells; Autologous hALK CAR T Cells; Autologous Anti-ALK CAR-T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-ALK CAR T-cell recognize and induce selective toxicity against ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.;

Details

Origin ID

C213795;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ALK Tyrosine Kinase Receptor [NCIt concept]

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