Preferred Label : ALK Inhibitor NVL-655;
NCIt synonyms : ALK Inhibitor NUV-655;
NCIt definition : An orally bioavailable, brain-penetrant, selective small molecule inhibitor of the
receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic
activity. Upon oral administration, ALK inhibitor NVL-655 specifically targets, binds
to and inhibits ALK fusion proteins and activating mutations, including the acquired
resistance mutations solvent front mutation (SFM) G1202R and the compound mutations
G1202R/L1196M and G1202R/G1269A. The inhibition of ALK leads to the disruption of
ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells.
ALK belongs to the insulin receptor superfamily and plays an important role in nervous
system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation
and gene rearrangements are associated with a variety of tumor cell types. NVL-655
is able to penetrate the blood-brain-barrier (BBB) and may therefore exert its activity
against EGFR-driven central nervous system (CNS) primary tumors and CNS metastases.;
Molecule name : NVL 655; NUV-655; NUV 655; NVL-655;
NCI Metathesaurus CUI : CL1792824;
Origin ID : C188054;
UMLS CUI : C5706448;
Semantic type(s)
- concept_is_in_subset
- has_target
