Preferred Label : Iruplinalkib;
NCIt synonyms : ALK Inhibitor WX-0593;
NCIt definition : An orally available, small molecule inhibitor of the receptor tyrosine kinase (RTK)
anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral
administration, iruplinalkib binds to and inhibits ALK tyrosine kinase, ALK fusion
proteins, ALK point mutation variants ALK L1196M, ALK C1156Y, and EGFR L858R/T790M.
Inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition
of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor
superfamily and plays an important role in nervous system development. ALK is not
expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements
are associated with a series of tumors. Additionally, ALK mutations are associated
with acquired resistance to small molecule tyrosine kinase inhibitors.;
UNII : Z5F65W1YAZ;
CAS number : 1854943-32-0;
Molecule name : WX 0593; FL-006; WX-0593; FL 006;
NCI Metathesaurus CUI : CL555276;
Origin ID : C154279;
UMLS CUI : C5706638;
Semantic type(s)
- concept_is_in_subset
- has_target
