" /> Anaplastic Lymphoma Kinase - CISMeF





Preferred Label : Anaplastic Lymphoma Kinase;

MeSH definition : A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.;

MeSH synonym : ALK Tyrosine Kinase Receptor; NPM-ALK; Anaplastic Lymphoma Receptor Tyrosine Kinase; Nucleophosmin-Anaplastic Lymphoma Kinase; Nucleophosmin Anaplastic Lymphoma Kinase; ALK Kinase; CD246 Antigen;

Registry Number MeSH : EC 2.7.10.1;

UNII : EC 2.7.10.1;

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A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

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10/05/2024


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