" /> ALK Inhibitor TAE684 - CISMeF





Preferred Label : ALK Inhibitor TAE684;

NCIt synonyms : NPM-ALK Inhibitor TAE684; 5-Chloro-n4-(2-(isopropylsulfonyl)phenyl)-n2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine;

NCIt related terms : TAE-684;

NCIt definition : A small molecule inhibitor of the receptor tyrosine kinases (RTKs) anaplastic lymphoma kinase (ALK) and nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), with potential antineoplastic activity. Upon administration, TAE684 binds to and inhibits ALK and NPM-ALK tyrosine kinases, which leads to a disruption of ALK- and NPM-ALK mediated signaling and eventually inhibits tumor cell growth in ALK- and NPM-ALK overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. NPM-ALK is an oncogenic fusion protein associated with ALK-positive anaplastic large cell lymphoma. ALK mutations are also associated with acquired resistance to small molecule tyrosine kinase inhibitors.;

UNII : EH1713MN4K;

InChIKey : QQWUGDVOUVUTOY-UHFFFAOYSA-N;

CAS number : 761439-42-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 761439-42-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TAE-684; TAE 684; NVP-TAE684;

NCI Metathesaurus CUI : CL1405839;

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12/05/2024


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