Preferred Label : Ficonalkib;
NCIt synonyms : ALK TKI SY-3505; ALK Inhibitor SY-3505;
NCIt definition : An orally bioavailable, third-generation inhibitor of the receptor tyrosine kinase
(RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon
oral administration, ficonalkib binds to and inhibits ALK wild-type tyrosine kinase
and numerous ALK mutations, including acquired resistance mutations. Inhibition of
ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth
in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and
plays an important role in nervous system development. ALK dysregulation and gene
rearrangements are associated with a variety of tumor cell types.;
UNII : 8EPZ3U4PSS;
CAS number : 2233574-95-1;
Molecule name : SY-3505; CT 3505; SY 3505; CT-3505;
NCI Metathesaurus CUI : CL1906480;
Origin ID : C199050;
UMLS CUI : C5855328;
Semantic type(s)
- concept_is_in_subset
- has_target
