ALK-FAK Inhibitor CEP-37440

Preferred Label : ALK-FAK Inhibitor CEP-37440;

NCIt related terms : CEP-37440;

NCIt definition : An orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis.;

UNII : O3MNS8782H;

CAS number : 1391712-60-9;

Molecule name : CEP-37440;

NCI Metathesaurus CUI : CL454076;

Details

Origin ID

C111685;

UMLS CUI

C3827144;

Currated CISMeF NLP mapping
- CEP-37440 [MeSH Supplementary Concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CEP-37440 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ALK Tyrosine Kinase Receptor [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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