" /> ALK-FAK Inhibitor CEP-37440 - CISMeF





Preferred Label : ALK-FAK Inhibitor CEP-37440;

NCIt related terms : CEP-37440;

NCIt definition : An orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis.;

UNII : O3MNS8782H;

CAS number : 1391712-60-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1391712-60-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CEP-37440;

NCI Metathesaurus CUI : CL454076;

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12/05/2024


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