Ceritinib - CISMeF

Preferred Label : Ceritinib;

NCIt synonyms : 2,4-Pyrimidinediamine, 5-chloro-N4-(2-((1-methylethyl)sulfonyl)phenyl)-N2-(5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl)-;

NCIt definition : An orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.;

UNII : K418KG2GET;

InChIKey : VERWOWGGCGHDQE-UHFFFAOYSA-N;

CAS number : 1032900-25-6;

Drug name : Zykadia;

Molecule name : LDK-378; LDK 378;

Codes from synonyms : 96;

Details

Origin ID

C115112;

UMLS CUI

C3818721;

Automatic exact mappings (from CISMeF team)
- ceritinib [ATC Code]
Currated CISMeF NLP mapping
- Ceritinib [ICD-11 Extension code]
- Ceritinib [SMS substance]
- Ceritinib (substance) [SNOMED CT concept]
- ceritinib [MeSH concept]
- ceritinib [International Nonproprietary Name]
- ceritinib [MeSH Supplementary Concept]
- ceritinib [Substance BNPC]
See also inter- (CISMeF)
- Product containing ceritinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ceritinib (substance) [SNOMED CT concept]
- Product containing ceritinib (medicinal product) [SNOMED CT concept]
- ceritinib [International Nonproprietary Name]
- ceritinib [Substance BNPC]
- ceritinib [MeSH Supplementary Concept]
- ceritinib [MeSH concept]
- ceritinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ALK Tyrosine Kinase Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Ceritinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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