Preferred Label : Carbon C 14 Gilteritinib;
NCIt synonyms : [14C] ASP2215; 14C-labeled Gilteritinib;
NCIt definition : A radioconjugate composed of gilteritinib, an inhibitor of the receptor tyrosine kinases
(RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and
anaplastic lymphoma kinase (ALK or CD246), labeled with the radioisotope carbon C
14, with potential use for evaluating the pharmacokinetic profile of gilteritinib.
Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL
and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction
pathways and the reduction of tumor cell proliferation in cancers that overexpress
these RTKs. Labeling of gilteritinib with the radioactive tracer carbon C 14 allows
for the evaluation of gilteritinib's pharmacokinetic profile, including its absorption,
distribution, metabolism, and excretion (ADME).;
Origin ID : C122677;
UMLS CUI : C4055274;
Semantic type(s)
- concept_is_in_subset
- has_target
