Tyrosine-Protein Kinase Receptor UFO

Preferred Label : Tyrosine-Protein Kinase Receptor UFO;

NCIt synonyms : AXL; AXL Protein; EC 2.7.10.1; AXL Oncogene;

NCIt definition : Tyrosine-protein kinase receptor UFO (894 aa, 98 kDa) is encoded by the human AXL gene. This protein plays a role in ligand binding, signaling and cellular growth and differentiation.;

NCIt note : A well characterized subtrate for tyrosine-protein kinase receptor UFO is growth arrest-specific protein 6.;

Details

Origin ID

C17475;

UMLS CUI

C1259415;

OMIM relation
- Axl receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- AXL protein, human [MeSH concept]
- AXL protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AXL Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_abnormality
- Protein Deregulation [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- AXL Inhibitor DS-1205c [NCIt concept]
- AXL Inhibitor NTQ2494 [NCIt concept]
- AXL Inhibitor SLC-391 [NCIt concept]
- AXL Receptor Tyrosine Kinase/cMET Inhibitor BPI-9016M [NCIt concept]
- AXL/FLT3 Inhibitor TT-00973 [NCIt concept]
- AXL/FLT3/NTRK Inhibitor HH30134 [NCIt concept]
- AXL/FLT3/VEGFR2 Inhibitor KC1036 [NCIt concept]
- Axl/Mer Inhibitor INCB081776 [NCIt concept]
- Axl/Mer Inhibitor PF-07265807 [NCIt concept]
- Axl/Mer/CSF1R Inhibitor Q702 [NCIt concept]
- Bemcentinib [NCIt concept]
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Carbon C 14 Gilteritinib [NCIt concept]
- Dubermatinib [NCIt concept]
- Enapotamab Vedotin [NCIt concept]
- Gilteritinib [NCIt concept]
- Gilteritinib Fumarate [NCIt concept]
- Mecbotamab Vedotin [NCIt concept]
- Mipasetamab Uzoptirine [NCIt concept]
- TAM/c-Met Inhibitor RXDX-106 [NCIt concept]
- Tamnorzatinib [NCIt concept]
- Zanzalintinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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