AXL Receptor Tyrosine Kinase/cMET Inhibitor BPI-9016M

Preferred Label : AXL Receptor Tyrosine Kinase/cMET Inhibitor BPI-9016M;

NCIt synonyms : AXL/cMET Inhibitor BPI-9016M;

NCIt definition : An orally available inhibitor of the AXL receptor tyrosine kinase (AXL; UFO) and the receptor tyrosine kinase c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Upon administration, AXL receptor tyrosine kinase/cMET inhibitor BPI-9016M, binds to both AXL and cMet, thereby disrupting both AXL- and c-Met-mediated signaling pathways. Altogether, this agent inhibits growth in AXL and cMet-overexpressing tumor cells. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases, and cMet, both overexpressed by many tumor cell types, play key roles in tumor cell proliferation, survival, invasion and metastasis.;

Molecule name : BPI-9016; BPI 9016; BPI-9016M;

NCI Metathesaurus CUI : CL520367;

Details

Origin ID

C132025;

UMLS CUI

C4329233;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Tyrosine-Protein Kinase Receptor UFO [NCIt concept]

Keyword's position in hierarchy(ies) :

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