Hepatocyte Growth Factor Receptor

Preferred Label : Hepatocyte Growth Factor Receptor;

NCIt synonyms : HGF-SF Receptor; MET Gene Product; HGFR; C-MET; SF Receptor; HGF Receptor; Tyrosine-Protein Kinase Met; Proto-Oncogene c-Met; HGF/SF Receptor; EC 2.7.10.1; Scatter Factor Receptor; MET;

NCIt definition : Hepatocyte growth factor receptor (1390 aa, 156 kDa) is encoded by the human MET gene. This protein is involved in tyrosine phosphorylation and ligand-dependent signaling.;

NCIt note : In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation. The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor. c-MET is related to the insulin receptor and ABL oncogene. (OMIM);

Details

Origin ID

C18186;

UMLS CUI

C1456828;

OMIM relation
- Met protooncogene, receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- MET protein, human [MeSH concept]
- MET protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MET Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- MET NP_000236.2:p.D1010N [NCIt concept]
- MET NP_000236.2:p.D1228N [NCIt concept]
- MET NP_000236.2:p.D1228X [NCIt concept]
- MET NP_000236.2:p.F1200I [NCIt concept]
- MET NP_000236.2:p.H1094Y [NCIt concept]
- MET NP_000236.2:p.I639L [NCIt concept]
- MET NP_000236.2:p.K324M [NCIt concept]
- MET NP_000236.2:p.L1205V [NCIt concept]
- MET NP_000236.2:p.M1250T [NCIt concept]
- MET NP_000236.2:p.Q1276L [NCIt concept]
- MET NP_000236.2:p.S1236R [NCIt concept]
- MET NP_000236.2:p.V1070E [NCIt concept]
- MET NP_000236.2:p.V1070G [NCIt concept]
- MET NP_000236.2:p.V1070M [NCIt concept]
- MET NP_000236.2:p.V1092I [NCIt concept]
- MET NP_000236.2:p.V504L [NCIt concept]
- MET NP_000236.2:p.Y1003X [NCIt concept]
- MET NP_000236.2:p.Y1230C [NCIt concept]
- MET NP_000236.2:p.Y1230H [NCIt concept]
- MET NP_000236.2:p.Y1230X [NCIt concept]
- MET Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Adherens Junction Stabilization Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- Neurotrophic Factor-Mediated NTRK1 Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- AXL Receptor Tyrosine Kinase/cMET Inhibitor BPI-9016M [NCIt concept]
- Amivantamab [NCIt concept]
- Amivantamab and Recombinant Human Hyaluronidase [NCIt concept]
- Anti-C-met Monoclonal Antibody SAIT301 [NCIt concept]
- Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T [NCIt concept]
- Anti-EGFR/c-Met Bispecific Antibody CKD-702 [NCIt concept]
- Anti-EGFR/c-Met/TOP1i ADC AZD9592 [NCIt concept]
- Anti-MET x MET Antibody Drug Conjugate REGN5093-M114 [NCIt concept]
- Anti-Met Monoclonal Antibody Mixture Sym015 [NCIt concept]
- Anti-Met/EGFR Monoclonal Antibody LY3164530 [NCIt concept]
- Anti-c-Met ADC ABBV-400 [NCIt concept]
- Anti-c-Met Antibody-drug Conjugate BYON3521 [NCIt concept]
- Anti-c-Met Antibody-drug Conjugate HTI-1066 [NCIt concept]
- Anti-c-Met Antibody-drug Conjugate TR1801 [NCIt concept]
- Anti-c-Met Monoclonal Antibody ARGX-111 [NCIt concept]
- Anti-c-Met Monoclonal Antibody HLX55 [NCIt concept]
- Anti-c-Met/EGFR/VEGF Trispecific Antibody TAVO412 [NCIt concept]
- Anti-c-Met/MMAE ADC MYTX-011 [NCIt concept]
- Anti-c-Met/MMAE ADC RC108 [NCIt concept]
- Bafisontamab [NCIt concept]
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Capmatinib [NCIt concept]
- Capmatinib Hydrochloride [NCIt concept]
- Crizotinib [NCIt concept]
- Davutamig [NCIt concept]
- Elzovantinib [NCIt concept]
- Emibetuzumab [NCIt concept]
- Foretinib [NCIt concept]
- Glesatinib [NCIt concept]
- Glioblastoma Multiforme Multipeptide Vaccine IMA950 [NCIt concept]
- Golvatinib [NCIt concept]
- Gumarontinib [NCIt concept]
- MET Kinase Inhibitor OMO-1 [NCIt concept]
- MET Tyrosine Kinase Inhibitor BMS-777607 [NCIt concept]
- MET Tyrosine Kinase Inhibitor EMD 1204831 [NCIt concept]
- MET Tyrosine Kinase Inhibitor PF-04217903 [NCIt concept]
- MET Tyrosine Kinase Inhibitor SAR125844 [NCIt concept]
- MET Tyrosine Kinase Inhibitor SGX523 [NCIt concept]
- Merestinib [NCIt concept]
- Onartuzumab [NCIt concept]
- Pamvatamig [NCIt concept]
- TAM/c-Met Inhibitor RXDX-106 [NCIt concept]
- Telisotuzumab [NCIt concept]
- Telisotuzumab Vedotin [NCIt concept]
- Tepotinib [NCIt concept]
- Tepotinib Hydrochloride [NCIt concept]
- Tivantinib [NCIt concept]
- Vebreltinib [NCIt concept]
- Zanzalintinib [NCIt concept]
- c-Met Inhibitor ABN401 [NCIt concept]
- c-Met Inhibitor AL2846 [NCIt concept]
- c-Met Inhibitor AMG 208 [NCIt concept]
- c-Met Inhibitor AMG 337 [NCIt concept]
- c-Met Inhibitor DO-2 [NCIt concept]
- c-Met Inhibitor GST-HG161 [NCIt concept]
- c-Met Inhibitor HS-10241 [NCIt concept]
- c-Met Inhibitor JNJ-38877605 [NCIt concept]
- c-Met Inhibitor MK2461 [NCIt concept]
- c-Met Inhibitor MK8033 [NCIt concept]
- c-Met Inhibitor SPH3348 [NCIt concept]
- c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084 [NCIt concept]
- cMet CAR-mRNA Electroporated Autologous T Lymphocytes [NCIt concept]

Keyword's position in hierarchy(ies) :

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