Preferred Label : Actinium Ac 225 FPI-2068;
NCIt synonyms : [225Ac]-FPI-2068; Actinium-225 FPI-2068; Actinium Ac 225-DOTA-FPI-2053; Targeted Alpha Therapeutic Agent FPI-2068; 225Ac FPI-2068; TAT Agent FPI-2068;
NCIt definition : A radioimmunoconjugate composed of FPI-2053, a humanized bispecific antibody targeting
epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR;
c-Met), chelated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and radiolabeled with the alpha-emitting radionuclide actinium Ac 225,
with potential antineoplastic activity. Upon administration of actinium Ac 225 FPI-2068,
the FPI-2053 moiety targets and binds to the extracellular domains of both EGFR and
c-Met expressed on certain cancer cells, thereby delivering a cytotoxic dose of alpha
radiation directly into EGFR- and c-Met-expressing tumor cells. Additionally, the
induction of apoptosis and subsequent release of tumor-associated antigens (TAAs)
from the tumor cells may induce an anti-tumor immune response, thereby further killing
tumor cells. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell
types, play key roles in tumor cell proliferation. EGFR and c-Met are co-expressed
on the surface of various cancer cell types while co-expression on normal, healthy
cells is minimal.;
Molecule name : FPI-2068; FPI 2068;
NCI Metathesaurus CUI : CL1928972;
Origin ID : C206445;
concept_is_in_subset
- has_target
