Gumarontinib - CISMeF

Preferred Label : Gumarontinib;

NCIt synonyms : Glumetinib;

NCIt definition : An orally bioavailable, small molecule inhibitor of the oncoprotein c-Met (hepatocyte growth factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration, gumarontinib targets and binds to the c-Met protein, thereby disrupting c-Met-dependent signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.;

UNII : 7JTT036WGX;

InChIKey : RYBLECYFLJXEJX-UHFFFAOYSA-N;

CAS number : 1642581-63-2;

Molecule name : SCC-244; SCC 244;

NCI Metathesaurus CUI : CL935869;

Détails

Origin ID

C156700;

UMLS CUI

C4745000;

Currated CISMeF NLP mapping
- glumetinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- glumetinib [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Hepatocyte Growth Factor Receptor [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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