" /> Gumarontinib - CISMeF





Preferred Label : Gumarontinib;

NCIt synonyms : Glumetinib;

NCIt definition : An orally bioavailable, small molecule inhibitor of the oncoprotein c-Met (hepatocyte growth factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration, gumarontinib targets and binds to the c-Met protein, thereby disrupting c-Met-dependent signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.;

UNII : 7JTT036WGX;

InChIKey : RYBLECYFLJXEJX-UHFFFAOYSA-N;

CAS number : 1642581-63-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1642581-63-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SCC-244; SCC 244;

NCI Metathesaurus CUI : CL935869;

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12/05/2024


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