Preferred Label : MET Kinase Inhibitor OMO-1;
NCIt synonyms : MET Tyrosine Kinase Inhibitor BMS-777607;
NCIt related terms : JNJ-38877618;
NCIt definition : An inhibitor of the proto-oncogene and receptor tyrosine kinase (RTK) hepatocyte growth
factor receptor (c-Met; HGFR; MET) with potential antineoplastic activity. Upon administration,
OMO-1 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting
c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing
c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor
tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles
in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.;
UNII : E0B2IZB5H5;
CAS number : 943540-74-7;
Molecule name : OMO-1; JNJ-38877618; JNJ 38877618;
NCI Metathesaurus CUI : CL551128;
Origin ID : C148537;
UMLS CUI : C4725111;
Semantic type(s)
- concept_is_in_subset
- has_target
