Preferred Label : Capmatinib;
NCIt synonyms : 2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide;
NCIt definition : An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte
growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib
selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting
c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing
c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor
tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles
in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.;
UNII : TY34L4F9OZ;
InChIKey : LIOLIMKSCNQPLV-UHFFFAOYSA-N;
CAS number : 1029712-80-8;
Molecule name : INCB028060; INCB 28060; INC-280; INCB28060; INC 280;
NCI Metathesaurus CUI : CL416248;
Codes from synonyms : 3231;
Origin ID : C90564;
UMLS CUI : C4053698;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- Manual BTNT mappings - CISMeF
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
