" /> Capmatinib Hydrochloride - CISMeF





Preferred Label : Capmatinib Hydrochloride;

NCIt definition : The hydrochloride salt form of capmatinib, an orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.;

UNII : C2A374O70X;

InChIKey : COWBUPJEEDYWKD-UHFFFAOYSA-N;

CAS number : 1865733-40-9;

Drug name : Tabrecta;

Molecule name : NVP-INC280-AAA;

NCI Metathesaurus CUI : CL526448;

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07/05/2025


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