NCIt definition : A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic
activity. c-Met inhibitor MK2461 preferentially inhibits activated c-Met in an ATP-competitive
manner, thereby inhibiting its tyrosine kinase activity, which may inhibit c-Met signaling
and result in cell growth inhibition in tumors that overexpress c-Met. c-Met, encoding
the hepatocyte growth factor receptor (HGFR) tyrosine kinase, plays an important role
in tumor cell proliferation and has been shown to be overexpressed or mutated in a
variety of cancers.;