Preferred Label : Anti-c-Met Antibody-drug Conjugate HTI-1066;
NCIt synonyms : ADC HTI-1066;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the tumor-associated
antigen (TAA) the proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) linked
to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity.
Upon intravenous administration, the monoclonal antibody moiety of HTI-1066 targets
and binds to c-Met expressed on tumor cells. Upon binding and internalization, the
cytotoxic agent is released and kills the c-Met-expressing cancer cells, through an
as of yet unknown mechanism of action. c-Met, a receptor tyrosine kinase overexpressed
or mutated in many tumor cell types, plays key roles in tumor cell proliferation,
survival, invasion, metastasis and tumor angiogenesis.;
Molecule name : HTI-1066; HTI 1066;
NCI Metathesaurus CUI : CL544636;
Origin ID : C146667;
UMLS CUI : C4688582;
Semantic type(s)
- concept_is_in_subset
- has_target
