" /> Foretinib - CISMeF





Preferred Label : Foretinib;

NCIt synonyms : Multitargeted Tyrosine Kinase Inhibitor GSK1363089; N-(3-Fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;

NCIt related terms : MET/VEGFR-2 inhibitor GSK1363089; XL880;

NCIt definition : An orally bioavailable small molecule with potential antineoplastic activity. Foretinib binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Foretinib blocks enzymes involved in the growth and spread of tumor cells. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.;

UNII : 81FH7VK1C4;

InChIKey : CXQHYVUVSFXTMY-UHFFFAOYSA-N;

CAS number : 849217-64-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 849217-64-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GSK1363089; XL880;

Chemical formula : C34H34F2N4O6;

Codes from synonyms : CDR0000549701; CDR0000666675; CDR0000675317;

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14/05/2024


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