Preferred Label : cMet CAR-mRNA Electroporated Autologous T Lymphocytes;
NCIt synonyms : cMet RNA CAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been electroporated with an mRNA
encoding a chimeric antigen receptor (CAR) consisting of an anti-human hepatocyte
growth factor receptor (HGFR or cMet) scFv (single chain variable fragment) and the
zeta chain of the TCR/CD3 complex (CD3-zeta) coupled to the co-stimulatory molecule
4-1BB (CD137), with potential antineoplastic activities. Upon intratumoral administration,
cMet CAR-mRNA electroporated autologous T lymphocytes direct T-cells to cMet-expressing
tumor cells, which induces a selective toxicity in cMet-expressing tumor cells and
causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances
activation and signaling after recognition of cMet. The inclusion of the 4-1BB signaling
domain may increase the antitumor activity as compared to the inclusion of the CD3-zeta
chain alone. The mRNA CAR is expressed for a limited amount of time, which can prevent
serious, unforeseen side effects. cMet, a receptor tyrosine kinase overexpressed or
mutated in many tumor cell types, plays a key role in cancer cell growth, survival,
angiogenesis, invasion, and metastasis.;
NCI Metathesaurus CUI : CL447406;
Origin ID : C106230;
UMLS CUI : C3831071;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
