Preferred Label : Anti-c-Met Antibody-drug Conjugate TR1801;
NCIt synonyms : Anti-c-Met ADC TR1801;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a non-agonizing anti-c-Met humanized
monoclonal antibody that is linked in a site-specific manner to a pyrrolobenzodiazepine
dimer (PBD) toxin, with potential antineoplastic activity. Upon administration, the
monoclonal antibody moiety targets and binds to the c-Met protein, which is overexpressed
in certain tumor types. Upon antibody/antigen binding and internalization, the imine
groups of the PBD moiety bind to the N2 positions of guanines on opposite strands
of tumor cell DNA. This induces interstrand cross-links in the minor groove of DNA
and inhibits DNA replication, which inhibits the proliferation of c-Met-expressing
cells. c-Met, also known as hepatocyte growth factor receptor (HGFR), is a receptor
tyrosine kinase that is overexpressed or mutated in many tumor cell types and plays
a key role in tumor cell proliferation, survival, invasion, metastasis, and tumor
angiogenesis.;
Molecule name : MT-8633; TR-1801; MT 8633; TR 1801;
NCI Metathesaurus CUI : CL938047;
Origin ID : C158513;
UMLS CUI : C4764264;
Semantic type(s)
- concept_is_in_subset
- has_target
