" /> Golvatinib - CISMeF





Preferred Label : Golvatinib;

NCIt synonyms : c-Met/VEGFR-2 Kinase Inhibitor E7050; 1,1-cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1-piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)-; c-Met VEGFR Kinase Inhibitor E7050;

NCIt definition : An orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.;

UNII : 516Z3YP58E;

InChIKey : UQRCJCNVNUFYDX-UHFFFAOYSA-N;

CAS number : 928037-13-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 928037-13-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : E7050;

Chemical formula : C33H37F2N7O4;

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11/05/2024


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