NCIt definition : A humanized monoclonal antibody targeting the alpha chain of the extracellular domain
of human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic
activity. Anti-c-Met monoclonal antibody SAIT301 binds to c-Met, thereby preventing
both binding of its ligand, HGF, and the subsequent activation of the HGF/c-Met signaling
pathway. In addition, SAIT301 induces c-MET internalization and subsequent degradation,
which further inhibits c-Met-mediated signaling. This leads to a reduction in the
proliferation of c-Met-expressing cancer cells. c-Met, a proto-oncogene receptor tyrosine
kinase overexpressed in certain cancer cell types, is involved in various tumors.;