Preferred Label : Anti-c-Met ADC ABBV-400;
NCIt synonyms : Anti-c-Met Antibody-drug Conjugate ABBV-400; ADC ABBV-400; ABBV400; c-Met ADC ABBV-400;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the tumor-associated
antigen (TAA) proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) linked
to an undisclosed topoisomerase inhibitor, with potential antineoplastic activity.
Upon intravenous administration of anti-c-Met ADC ABBV-400, the monoclonal antibody
moiety targets and binds to c-Met expressed on tumor cells. Upon binding and internalization,
the topoisomerase inhibitor is released, which binds to and inhibits topoisomerase,
thereby inhibiting DNA replication and killing the c-Met-expressing cancer cells.
c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types,
plays key roles in tumor cell proliferation, survival, invasion, metastasis and tumor
angiogenesis.;
Molecule name : ABBV 400; ABBV-400;
NCI Metathesaurus CUI : CL1772553;
Origin ID : C184368;
UMLS CUI : C5666919;
Semantic type(s)
- concept_is_in_subset
- has_target
