Preferred Label : MET Tyrosine Kinase Inhibitor PF-04217903;
NCIt synonyms : 2-(4-(1-(Quinolin-6-ylmethyl)-1H-(1,2,3)triazolo(4,5-b)pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol;
NCIt related terms : PF-04217903;
NCIt definition : An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic
activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits
c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition
of tumor cell growth, migration and invasion of tumor cells, and the induction of
death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known
as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor
cell types, playing an important role in tumor cell proliferation, survival, invasion,
and metastasis and angiogenesis.;
UNII : CYJ9ATV1IJ;
InChIKey : PDMUGYOXRHVNMO-UHFFFAOYSA-N;
CAS number : 956905-27-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 956905-27-4
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G-SRS /a ;
Molecule name : PF-04217903;
Origin ID : C78483;
UMLS CUI : C2703125;
- CISMeF manual mappings
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