Preferred Label : PF-04217903 Monophosphate;
NCIt synonyms : 1H-Pyrazole-1-ethanol, 4-(1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo(4,5-b)pyrazin-6-yl)-,
Phosphate (1:1);
NCIt definition : The monophosphate form of PF-04217903, an orally bioavailabe, small-molecule tyrosine
kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor
PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling
pathway, which may result in the inhibition of tumor cell growth, migration and invasion
of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor
tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed
or mutated in many tumor cell types, playing an important role in tumor cell proliferation,
survival, invasion, and metastasis and angiogenesis.;
UNII : E1E1K0PK8V;
InChIKey : TWWONGIWZWOGQN-UHFFFAOYSA-N;
CAS number : 1159490-83-1;
NCI Metathesaurus CUI : CL539504;
Origin ID : C141443;
UMLS CUI : C4683821;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
