Preferred Label : Anti-Met/EGFR Monoclonal Antibody LY3164530;
NCIt related terms : LY-3164530;
NCIt definition : A monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR)
and human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic
activity. Upon administration, anti-Met/EGFR MoAb LY3164530 targets and prevents the
activation of EGFR and c-Met. This leads to a downstream inhibition of EGFR/c-Met-mediated
signal transduction pathways, and prevents cellular proliferation in tumor cells overexpressing
EGFR and c-Met. EGFR, a member of the epidermal growth factor family of extracellular
protein ligands, may be overexpressed on the cell surface of various solid tumor cell
types. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell
types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and
metastasis.;
UNII : K85WE44TZ7;
CAS number : 2069210-01-9;
Molecule name : LY3164530;
NCI Metathesaurus CUI : CL474133;
Origin ID : C118281;
UMLS CUI : C3896820;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
