MET Tyrosine Kinase Inhibitor BMS-777607NCIt concept
Preferred Label : MET Tyrosine Kinase Inhibitor BMS-777607;
NCIt related terms : BMS-777607;
NCIt definition : An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine
kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor
(HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET
signaling pathway; this agent may induce cell death in tumor cells expressing c-Met.
c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types,
plays an important role in tumor cell proliferation, survival, invasion, and metastasis,
and in tumor angiogenesis.;
UNII : A3MMS6HDO1;
CAS number : 1025720-94-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1025720-94-8
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