Cabozantinib S-malate

Preferred Label : Cabozantinib S-malate;

NCIt synonyms : Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1);

NCIt definition : The s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.;

UNII : DR7ST46X58;

InChIKey : HFCFMRYTXDINDK-WNQIDUERSA-N;

CAS number : 1140909-48-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1140909-48-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Cometriq; Cabometyx;

Molecule name : BMS-907351; XL-184;

Chemical formula : C28H24FN3O5.C4H6O5;

Details

Origin ID

C97938;

UMLS CUI

C3468008;

Currated CISMeF NLP mapping
- Cabozantinib s-malate (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Cabozantinib [NCIt concept]
has_target
- Angiopoietin-1 Receptor [NCIt concept]
- BDNF/NT-3 Growth Factors Receptor [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Tyrosine-Protein Kinase Receptor UFO [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_component_of_chemotherapy_regimen
- Cabozantinib Regimen [NCIt concept]
- Cabozantinib/Nivolumab Regimen [NCIt concept]
is_salt_form_of
- Cabozantinib [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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