Angiopoietin-1 Receptor

Preferred Label : Angiopoietin-1 Receptor;

NCIt synonyms : Epithelial-Specific Protein Receptor Tyrosine Kinase TIE-2; Tyrosine-Protein Kinase Receptor TEK; Tunica Interna Endothelial Cell Kinase; Angiopoietin 1 Receptor; TEK Tyrosine Kinase, Endothelial; Endothelial TEK Tyrosine Kinase; Tyrosine-Protein Kinase Receptor TIE-2; p140 TEK; CD202B Antigen; EC 2.7.10.1; Endothelial Tyrosine Kinase; TEK Tyrosine Kinase; CD202b; Tyrosine Kinase with Ig and EGF Homology Domains-2; hTIE2;

NCIt definition : Angiopoietin-1 receptor (1124 aa, 126 kDa) is encoded by the human TEK gene. This protein is involved in angiopoietin signaling, tyrosine phosphorylation and endothelial cell maintenance.;

NCIt note : Protein_Malfunction_Associated_With_Disease: VMCM; Protein_Activated_By: ANG1, ANG2; Protein_Has_Structural_Domain_Or_Motif: Ig-Like C2 Domain, FN III-Like Domain; Protein_Interacts_With: ANG1, ANG2; Protein_Expressed_In_Tissue: Angioblast; Protein_Has_Malfunction_Type: Activation/Gain-of-Function, Deficiency; Protein_Plays_Role_In_Biological_Process: Cell Patterning, Vascular Morphogenesis; Protein_Family: TIE Family; The tie2 receptor, its activating ligand angiopoietin-1 and the inhibitory ligand angiopoietin-2 constitute a pathway for regulation of angiogenesis.;

Details

Origin ID

C18488;

UMLS CUI

C3853567;

Automatic exact mappings (from CISMeF team)
- TEK receptor tyrosine kinase [ORDO Gene]
- TEK receptor tyrosine kinase [HGNC gene]
- Tek tyrosine kinase, endothelial [OMIM gene]
OMIM relation
- Tek tyrosine kinase, endothelial [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TEK protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- TEK Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelium [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- TEK NP_000450.2:p.N452D [NCIt concept]
- TEK Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- EGF-Like Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Morphogenesis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241 [NCIt concept]
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Glesatinib [NCIt concept]
- Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981 [NCIt concept]
- Pexmetinib [NCIt concept]
- Ponatinib [NCIt concept]
- Ponatinib Hydrochloride [NCIt concept]
- Rebastinib [NCIt concept]
- Rebastinib Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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