Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret

Preferred Label : Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret;

NCIt synonyms : EC 2.7.10.1; Glial Cell Line Derived Neurotrophic Factor Receptor Component; Hydroxyaryl-Protein Kinase; RET Protein; Tyrosine-Protein Kinase Receptor RET; Proto-Oncogene c-Ret; Cadherin Family Member 12; RET;

NCIt definition : Proto-oncogene tyrosine-protein kinase receptor Ret (1114 aa, 124 kDa) is encoded by the human RET gene. This protein plays a role in the proliferation, migration and differentiation of neural cells.;

Details

Origin ID

C18539;

UMLS CUI

C0389252;

Automatic exact mappings (from CISMeF team)
- Protein-tyrosine kinase (substance) [SNOMED CT concept]
- Proto-oncogene tyrosine-protein kinase receptor RET (substance) [SNOMED CT concept]
- RET proto-oncogene (substance) [SNOMED CT concept]
- Rearranged during transfection protooncogene [OMIM Phenotype]
- Ret protooncogene [OMIM gene]
- isatidine [MeSH Supplementary Concept]
- megakaryocyte-associated tyrosine kinase [HGNC gene]
- protein-tyrosine kinases [MeSH Descriptor]
- ret (qualifier value) [SNOMED CT concept]
- ret proto-oncogene [ORDO Gene]
Currated CISMeF NLP mapping
- RET protein, human [MeSH concept]
- RET protein, human [MeSH Supplementary Concept]
OMIM relation
- Rearranged during transfection protooncogene [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- RET protein, human [MeSH concept]
- RET protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RET Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Adhesion Molecule [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Adrenal Gland Pheochromocytoma [NCIt concept]
- Multiple Endocrine Neoplasia [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Enbezotinib [NCIt concept]
- Motesanib Diphosphate [NCIt concept]
- Pralsetinib [NCIt concept]
- RET Inhibitor APS03118 [NCIt concept]
- RET Inhibitor EP0031 [NCIt concept]
- RET Inhibitor FHND5071 [NCIt concept]
- RET Inhibitor HS-10365 [NCIt concept]
- RET Inhibitor KL590586 [NCIt concept]
- RET Inhibitor LOXO-260 [NCIt concept]
- RET Inhibitor SY-5007 [NCIt concept]
- RET Inhibitor TY-1091 [NCIt concept]
- Regorafenib [NCIt concept]
- Regorafenib Hydrate [NCIt concept]
- Selpercatinib [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 [NCIt concept]
- Vepafestinib [NCIt concept]
- Zeteletinib [NCIt concept]
- Zeteletinib Adipate [NCIt concept]

Keyword's position in hierarchy(ies) :

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