Preferred Label : Vepafestinib;
NCIt synonyms : RET Inhibitor TAS0953/HM06;
NCIt definition : An orally bioavailable selective inhibitor of wild-type, fusion products and mutated
forms of the proto-oncogene receptor tyrosine kinase rearranged during transfection
(RET), with potential antineoplastic activity. Upon oral administration, vepafestinib
selectively binds to and inhibits the activity of RET. This results in an inhibition
of cell growth of tumors cells that exhibit increased RET activity. RET overexpression,
activating mutations, and fusions result in the upregulation and/or overactivation
of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET
activity plays a key role in the development and progression of these cancers.;
UNII : LF333FK2V5;
CAS number : 2129515-96-2;
Molecule name : TAS0953/HM06;
NCI Metathesaurus CUI : CL1642767;
Origin ID : C176968;
UMLS CUI : C5706694;
Semantic type(s)
- concept_is_in_subset
- has_target
