" /> Regorafenib - CISMeF





Preferred Label : Regorafenib;

NCIt synonyms : BAY 73-4506; 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide; Multitargeted Receptor Tyrosine Kinase Inhibitor BAY 73-4506;

NCIt related terms : REGORAFENIB ANHYDROUS;

NCIt definition : The anhydrous form of regorafenib, an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling.;

UNII : 24T2A1DOYB;

InChIKey : FNHKPVJBJVTLMP-UHFFFAOYSA-N;

CAS number : 755037-03-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 755037-03-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C21H15ClF4N4O3;

Codes from synonyms : 438;

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14/05/2024


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