Preferred Label : Regorafenib;
NCIt synonyms : BAY 73-4506 Monohydrate; Regorafenib Monohydrate; 2-Pyridinecarboxamide, 4-(4-((((4-Chloro-3-(Trifluoromethyl)Phenyl)Amino)Carbonyl)Amino)-3-Fluorophenoxy)-N-Methyl-,
Hydrate (1:1); BAY-73-4506 Monohydrate;
NCIt definition : The hydrate form of regorafenib, an orally bioavailable small molecule with potential
antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular
endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf
kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation.
VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis;
the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific
Raf kinase are involved in tumor cell signaling.;
UNII : MGN125FS9D;
CAS number : 1019206-88-2;
Drug name : Stivarga;
NCI Metathesaurus CUI : CL1772908;
Origin ID : C184955;
UMLS CUI : C3537697;
Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
