" /> RET Inhibitor KL590586 - CISMeF





Preferred Label : RET Inhibitor KL590586;

NCIt definition : An orally bioavailable inhibitor of the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, RET inhibitor SY-5007 selectively binds to and inhibits the activity of RET. This results in an inhibition of cell growth of tumors that exhibit increased RET activity. RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers.;

Molecule name : KL-590586; KL 590586;

NCI Metathesaurus CUI : CL1792034;

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31/07/2025


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