Multiple Endocrine Neoplasia

Preferred Label : Multiple Endocrine Neoplasia;

NCIt synonyms : MEN;

NCIt related terms : MEN syndrome; Multiple Endocrine Neoplasia Syndrome(s); Endocrine adenomatosis; multiple endocrine neoplasia syndrome; multiple endocrine adenomatosis; MEN Syndromes; Multiple endocrine adenomas;

NCIt definition : An autosomal dominant inherited neoplastic syndrome characterized by the development of various endocrine neoplasms and abnormalities in various anatomic sites. There are four types recognized: type 1 (MEN 1), caused by inactivation of the tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET gene, type 2B (MEN 2B) also caused by mutation of the RET gene, and type 4 (MEN 4) caused by mutation of the CDKN1B gene. Patients with MEN 1 may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid carcinomas and may also develop pheochromocytomas and parathyroid gland hyperplasia. Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural defects including neuromas. Patients with MEN 4 develop endocrine neoplasms, particularly in the parathyroid glands, pituitary, and pancreas.;

Alternative definition : NCI-GLOSS: An inherited condition that may result in the development of cancers of the endocrine system. There are several types of multiple endocrine neoplasia syndrome, and patients with each type may develop different types of cancer. The altered genes that cause each type can be detected with a blood test.; NICHD: A genetically heterogenous group of autosomal dominant neoplastic syndromes characterized by the development of neoplasms in various endocrine organs.;

Neoplastic status : Undetermined;

ICD-O code : 8360/1;

Codes from synonyms : CDR0000270863; CDR0000563964; CDR0000044551;

Details

Origin ID

C6432;

UMLS CUI

C0027662;

Currated CISMeF NLP mapping
- Multiple endocrine adenomas [ICD-11 Extension code]
- Multiple endocrine adenomas (morphologic abnormality) [SNOMED CT concept]
- Multiple endocrine adenomatosis [MedDRA LLT]
- Multiple endocrine adenomatosis NOS [MedDRA LLT]
- Multiple endocrine neoplasia [PASCAL descriptor]
- Multiple endocrine neoplasia [MedDRA Preferred Term]
- Multiple endocrine neoplasia [ORDO Disease]
- Multiple endocrine neoplasia syndromes [MedDRA High Level Term]
- Multiple endocrine neoplasias [MedDRA High Level Term]
- Multiple polyglandular tumor [ORDO Disease]
- Polyglandular activity in multiple endocrine adenomatosis (disorder) [SNOMED CT concept]
- multiple endocrine adenomas [SNOMED Notion]
- multiple endocrine neoplasia [Disease (Nov.)]
- multiple endocrine neoplasia [DO Concept]
- multiple endocrine neoplasia [MeSH Descriptor]
- multiple endocrine neoplasia [MeSH concept]
- polyglandular activity in multiple endocrine adenomatosis [SNOMED Notion]
Disease excludes abnormal cell
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease excludes normal cell origin
- Thyroid Gland Follicular Cell [NCIt concept]
False automatic mappings
- Man (person) [SNOMED CT concept]
- men [MedlinePlus Group]
- men [MeSH Descriptor]
- men [MeSH concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Multiple endocrine adenomas (morphologic abnormality) [SNOMED CT concept]
- Multiple endocrine adenomatosis [MedDRA LLT]
- Multiple endocrine adenomatosis NOS [MedDRA LLT]
- Multiple endocrine neoplasia [MedDRA Preferred Term]
- Multiple endocrine neoplasia [ORDO Disease]
- Multiple endocrine neoplasia syndromes [MedDRA High Level Term]
- Multiple endocrine neoplasias [MedDRA High Level Term]
- Multiple polyglandular tumor [ORDO Disease]
- multiple endocrine adenomas [SNOMED Notion]
- multiple endocrine neoplasia [MeSH Descriptor]
- multiple endocrine neoplasia [MeSH concept]
Validated automatic mappings to BTNT
- Multiple endocrine neoplasia, type I [OMIM Phenotype]
associated_with_malfunction_of_gene_product
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret [NCIt concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Endocrinology Terminology [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_associated_gene
- Oncogene RET [NCIt concept]
disease_has_finding
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Multifocal Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
related_to_genetic_biomarker
- CDKN1B Gene [NCIt concept]
- MEN1 Gene [NCIt concept]
- RET Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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