Preferred Label : Sunitinib Malate;
NCIt synonyms : Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(1:1);
NCIt related terms : Sutent; SU11248; sunitinib; SU011248;
NCIt definition : The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor
with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities
of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth
factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation.
This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3),
another receptor tyrosine kinase expressed by some leukemic cells.;
Alternative definition : NCI-GLOSS: A drug used to treat gastrointestinal stromal tumors (GIST) that have not
responded to treatment with imatinib mesylate (Gleevec). SU011248 is also used to
treat advanced kidney cancer and is being studied in the treatment of other types
of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial
growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.;
UNII : LVX8N1UT73;
InChIKey : LBWFXVZLPYTWQI-IPOVEDGCSA-N;
CAS number : 341031-54-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 341031-54-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Sutent;
Molecule name : SU011248; SU11248;
Chemical formula : C22H27FN4O2.C4H6O5;
NSC code : 736511;
Codes from synonyms : CDR0000306520; 32183; CDR0000468779; CDR0000492233; CDR0000492234; CDR0000492235;
Origin ID : C26673;
UMLS CUI : C1700685;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
