Sunitinib Malate

Preferred Label : Sunitinib Malate;

NCIt synonyms : Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1);

NCIt related terms : Sutent; SU11248; sunitinib; SU011248;

NCIt definition : The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.;

Alternative definition : NCI-GLOSS: A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). SU011248 is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.;

UNII : LVX8N1UT73;

InChIKey : LBWFXVZLPYTWQI-IPOVEDGCSA-N;

CAS number : 341031-54-7;

Drug name : Sutent;

Molecule name : SU 11248; SU-11248; SU-011248; SU 011248;

Chemical formula : C22H27FN4O2.C4H6O5;

NSC code : 736511;

Codes from synonyms : CDR0000306520; 32183; CDR0000468779; CDR0000492233; CDR0000492234; CDR0000492235;

Details

Origin ID

C26673;

UMLS CUI

C1700685;

Automatic exact mappings (from CISMeF team)
- Sunitinib (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing sunitinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Sunitinib [MeSH Descriptor]
- Sunitinib [LOINC component]
- Sunitinib [SMS substance]
- sunitinib [MeSH concept]
chemical_or_drug_affects_gene_product
- Receptor Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Sunitinib [NCIt concept]
has_target
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_component_of_chemotherapy_regimen
- Sunitinib Regimen [NCIt concept]
is_salt_form_of
- Sunitinib [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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