Papillary Thyroid Carcinoma Pathway

Preferred Label : Papillary Thyroid Carcinoma Pathway;

NCIt synonyms : Thyroid Cancer Pathway; PTC Pathway;

NCIt related terms : Thyroid cancer;

Alternative definition : KEGG: Papillary thyroid carcinoma (PTC), the most frequent neoplasia originating from the thyroid epithelium, accounts for about 80% of all thyroid cancers. Chimeric oncogenes, created by chromosomal rearrangements involving prevalently RET and, to a less extent, NTRK1 loci, are implicated in the development of papillary carcinoma. These are inappropriately expressed and stimulate constitutive signaling, bypassing the need for receptor activation by growth factors. Alternatively, mutant RAS directly stimulates BRAF, whereas mutant BRAF directly stimulates MEK.;

KEGG ID : hsa05216;

Details

Origin ID

C91496;

UMLS CUI

C2984307;

Automatic exact mappings (from CISMeF team)
- Malignant neoplasms of thyroid gland [ICD-11 Category]
- Malignant tumor of thyroid gland (disorder) [SNOMED CT concept]
- Thyroid cancer [MedDRA Preferred Term]
- Thyroid cancer [PASCAL descriptor]
- Thyroid cancer [HPMULTI term]
- thyroid cancer [MedlinePlus Topic]
- thyroid cancer [Radlex concept]
- thyroid gland cancer [DO Concept]
- thyroid neoplasms [MeSH Descriptor]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Cadherin-1 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Coiled-Coil Domain-Containing Protein 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Nuclear Receptor Coactivator 4 [NCIt concept]
- Nucleoprotein TPR [NCIt concept]
- Paired Box Protein Pax-8 [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Gamma [NCIt concept]
- Protein TFG [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Tropomyosin Alpha-3 Chain [NCIt concept]
pathway_has_gene_element
- BRAF wt Allele [NCIt concept]
- CCDC6 wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NCOA4 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NTRK1 wt Allele [NCIt concept]
- PAX8 wt Allele [NCIt concept]
- PPARG wt Allele [NCIt concept]
- RET wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- RXRB wt Allele [NCIt concept]
- RXRG wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TFG wt Allele [NCIt concept]
- TPM3 wt Allele [NCIt concept]
- TPR wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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