NCIt definition : Human NTRK1 wild-type allele is located within 1q21-q22 and is approximately 21 kb
in length. This allele, which encodes high affinity nerve growth factor receptor protein,
is involved in cellular differentiation, signal transduction and may play a role in
specifying sensory neuron subtypes. Defects in the gene have been associated with
neoroblastomas and thyroid tumors. Further, mutations in the gene are associated with
congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation
and several other cancers.;