NCIt definition : Human PPARG wild-type allele is located in the vicinity of 3p25 and is approximately
146 kb in length. This allele, which encodes peroxisome proliferator-activated receptor
gamma protein, plays a role in adipocyte differentiation. The gene has been implicated
in the pathology of numerous diseases including obesity, diabetes, atherosclerosis
and cancer. Mutations in the gene can lead to type 2 insulin-resistant diabetes, hypertension,
obesity, colon cancer, familial partial lipodystrophy type 3 and carotid intimal medial
thickness 1.;