Preferred Label : PPAR Pathway;
NCIt related terms : Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression;
Alternative definition : BIOCARTA: Similar to other nuclear hormone receptors, PPAR acts as a ligand activated
transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa interacts
with RXR and regulates the expression of target genes. These genes are involved in
the catabolism of fatty acids. Conversely, PPARg is activated by prostaglandins, leukotrienes,
and anti-diabetic thiazolidinediones and affects the expression of genes involved
in the storage of the fatty acids. PPARb is only weakly activated by fatty acids,
prostaglandins, and leukotrienes and has no known physiologically relevant ligand.
However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism
and perhaps in skin proliferation and cancer. (This definition may be outdated - see
the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_pparPathway;
Origin ID : C39199;
UMLS CUI : C1518804;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
