Retinoic Acid Receptor RXR-Alpha

Preferred Label : Retinoic Acid Receptor RXR-Alpha;

NCIt synonyms : RXRA; Retinoid X Receptor A; Nuclear Receptor Subfamily 2 Group B Member 1; Retinoid X Receptor Alpha; NR2B1;

NCIt definition : Retinoic acid receptor RXR-alpha (462 aa, 51 kDa) is encoded by the human RXRA gene. This protein is involved in both binding to 9-cis retinoic acid and transcriptional regulation.;

NCIt note : Retinoic acid receptor RXR-alpha can form heterodimers with retinoic acid receptor alpha, peroxisome proliferator-activated receptor alpha or peroxisome proliferator-activated receptor gamma. (UniProt);

Details

Origin ID

C38416;

UMLS CUI

C3887580;

Currated CISMeF NLP mapping
- retinoid X receptor alpha [MeSH concept]
- retinoid x receptor alpha [MeSH Descriptor]
OMIM relation
- Retinoid X receptor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- RXRA Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Retinoic Acid Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- CARM1 Transcription Regulation Pathway [NCIt concept]
- Chromatin Remodeling Complex and Coactivator Pathway [NCIt concept]
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Metabolic Syndrome Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Obesity and Thermogenesis Pathway [NCIt concept]
- PPAR Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- RAR and RXR Degradation Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- Regulation of Cholesterol Metabolism Pathway [NCIt concept]
- Retinoic Acid Receptor Family-Mediated Signaling Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cholesterol Homeostasis [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- RXR-alpha Variant-targeting Agent NM6603 [NCIt concept]

Keyword's position in hierarchy(ies) :

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