Retinoic Acid Receptor

Preferred Label : Retinoic Acid Receptor;

NCIt synonyms : RAR; Nuclear Receptor Subfamily 1 Group B; Retinoid Receptor; NR1B;

NCIt definition : Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.;

NCIt note : A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI);

Details

Origin ID

C17532;

UMLS CUI

C0140278;

Automatic exact mappings (from CISMeF team)
- Acquired idiopathic sideroblastic anemia [ORDO Disease]
- Refractory anemia with sideroblasts (morphologic abnormality) [Inactive SNOMED CT concept]
- retinoic acid receptor alpha [ORDO Gene]
- retinoid x receptors [MeSH Descriptor]
Biochemical function of gene products
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
Currated CISMeF NLP mapping
- receptors, retinoic acid [MeSH Descriptor]
- receptors, retinoic acid [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, retinoic acid [MeSH Descriptor]
- receptors, retinoic acid [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Alitretinoin [NCIt concept]
- Fenretinide [NCIt concept]
- Fenretinide Lipid Matrix [NCIt concept]
- Fenretinide Phospholipid Suspension ST-001 [NCIt concept]
- Isotretinoin [NCIt concept]
- Tretinoin [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Fenretinide [NCIt concept]
- Fenretinide Lipid Matrix [NCIt concept]
- Isotretinoin [NCIt concept]
- Retinoid 9cUAB30 [NCIt concept]
- Tretinoin [NCIt concept]

Keyword's position in hierarchy(ies) :

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