Fenretinide Phospholipid Suspension ST-001

Preferred Label : Fenretinide Phospholipid Suspension ST-001;

NCIt synonyms : nanoFenretinide ST-001;

NCIt definition : An intravenous formulation composed of a phospholipid suspension of nanoparticles containing the synthetic retinoid derivative fenretinide, with potential antineoplastic activity. Upon intravenous administration, fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in susceptible tumor cell types. Fenretinide also binds to and inhibits the activity of mammalian target of rapamycin (mTOR), which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Independent of RAR activation and mTOR inhibition, this agent may also modulate gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS).;

Molecule name : ST 001; ST-001;

NCI Metathesaurus CUI : CL1412852;

Details

Origin ID

C175469;

UMLS CUI

C5446550;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Retinoic Acid Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Retinoic Acid Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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