Preferred Label : Tretinoin;
NCIt synonyms : All-trans Vitamin A Acid; (All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic
Acid; Tretinoinum; Trans Vitamin A Acid; Retinoic Acid; Trans Retinoic Acid; beta-Retinoic Acid; ATRA; trans-Retinoic Acid;
NCIt related terms : Renova; all trans-Retinoic acid; Retin-A-Micro; Avita; all-trans-Retinoic acid; Aknoten; Dermairol; Vitamin A acid, all-trans-; Eudyna; Retin-A; all-trans-Vitamin A acid; 2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-,
(all-E)-; Vesanoid; all-trans retinoic acid; Aberel; Airol; vitamin A acid;
NCIt definition : A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid
receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation,
decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits
telomerase, resulting in telomere shortening and eventual apoptosis of some tumor
cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.;
Alternative definition : NCI-GLOSS: A nutrient that that body needs in small amounts to function and stay healthy.
All-trans retinoic acid is made in the body from vitamin A and helps cells to grow
and develop, especially in the embryo. A form of all-trans retinoic acid made in the
laboratory is put on the skin to treat conditions such as acne and is taken by mouth
to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too
many immature blood-forming cells in the blood and bone marrow). All-trans retinoic
acid is being studied in the prevention and treatment of other types of cancer.;
UNII : 5688UTC01R;
InChIKey : SHGAZHPCJJPHSC-YCNIQYBTSA-N;
CAS number : 302-79-4;
Drug name : Retisol-A; Dermairol; Retin-A MICRO; Retin-A; Epi-Aberel; Stieva-A; Renova; Vitinoin; Airol; Eudyna; Aberel; Aknoten; Avita; Cordes Vas; Stieva-A Forte; Vesanoid;
Molecule name : Ro 5488;
Chemical formula : C20H28O2;
NSC code : 122758;
ChEBI ID : CHEBI:15367;
Codes from synonyms : CDR0000367465; CDR0000410739; CDR0000410738; CDR0000467819; 00404; CDR0000045351; CDR0000467823; CDR0000467820; NSC0122758; CDR0000467821; CDR0000467822; CDR0000410740; 20;
Origin ID : C900;
UMLS CUI : C0040845;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
