" /> Isotretinoin - CISMeF





Preferred Label : Isotretinoin;

NCIt synonyms : cis-Retinoic Acid; 13-cis-Vitamin A Acid; 13-cis-Retinoic Acid; 13-cis-Retinoate; Neovitamin A; Isotretinoinum; 13-cRA; Retinoicacid-13-cis; Neovitamin A Acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid;

NCIt related terms : 13-cis retinoic acid;

NCIt definition : A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.;

Alternative definition : NCI-GLOSS: A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.;

UNII : EH28UP18IF;

InChIKey : SHGAZHPCJJPHSC-XFYACQKRSA-N;

CAS number : 4759-48-2;

Drug name : Roaccutan; Roacutan; Roaccutane; Cistane; Accutane; Claravis; Amnesteem; Sotret; Accure; Oratane; Isotrexin; Isotrex; Myorisan; ZENATANE; Absorica;

Molecule name : Ro-4-3780; Ro 4-3780;

Chemical formula : C20H28O2;

NSC code : 329481;

ChEBI ID : CHEBI:6067;

Codes from synonyms : CDR0000045534; CDR0000044428; 00239; 285;

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27/05/2025


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