NCIt definition : A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin
binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve
as transcription factors that promote cell differentiation and apoptosis. This agent
also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine
decarboxylase, thereby decreasing polyamine synthesis and keratinization.;
Alternative definition : NCI-GLOSS: A drug that is used in the treatment of acne and psoriasis and is being
studied in cancer prevention. It is a type of retinoid.;
UNII : EH28UP18IF;
InChIKey : SHGAZHPCJJPHSC-XFYACQKRSA-N;
CAS number : 4759-48-2;
Drug name : Roaccutan; Roacutan; Roaccutane; Cistane; Accutane; Claravis; Amnesteem; Sotret; Accure; Oratane; Isotrexin; Isotrex; Myorisan; ZENATANE; Absorica;
Molecule name : Ro-4-3780; Ro 4-3780;
Chemical formula : C20H28O2;
NSC code : 329481;
ChEBI ID : CHEBI:6067;
Codes from synonyms : CDR0000045534; CDR0000044428; 00239; 285;